Abstract:Amantadine is an antiviral drug, which can improve the symptoms of Parkinson's disease and prevent influenza virus. Because of its low price and good anti-influenza Virus effect, it is often used to prevent and control avian influenza. However, excessive use of amantadine can produce residues in the environment and food, along with drug resistance of viruses, and pass through food chain to the human body with potential hazard to human health, which posing certain ecological risk and food safety risk. Although various countries have started to restrict the use of amantadine, the residues of amantadine can still be detected in some foods on the market. In this study, the hazard, instrumental analysis detection methods, and residual risks of amantadine in food were reviewed, in order to provide references for the detection of amantadine residues in animals and plants, as well as the assessment of food and ecological safety risks brought by amantadine. [Chinese Fishery Quality and Standards, 2022, 12(3): 64-71]