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全氟羧酸及其前体物质的环境分布、毒性和生物转化研究进展
作者: 郭萌萌 谭志军 吴海燕 郑关超 付树林 彭吉星 李风铃 翟毓秀* 
单位: (国家水产品质量监督检验中心 中国水产科学研究院黄海水产研究所 山东 青岛 266071) 
关键词: 全氟羧酸及其前体物质 环境分布 生物转化 毒性 水生生物 
分类号:S94
出版年,卷(期):页码:2018,8(4):25-37
文章下载
摘要:

全氟羧酸(perfluorocarboxylic acids, PFCAs)为具有生物富集性、多脏器毒性和潜在致癌性的一类全氟烷基物质,其在环境和生物介质中广泛存在。研究表明,PFCAs的前体物质为生物体内PFCAs污染的间接来源,因此PFCAs的前体物质在近年来受到了越来越多的关注。文章以PFCAs及其前体物质的环境分布、毒性和生物转化等方面为视角总结研究进展。水环境是PFCAs及其前体物质存在的重要媒介,膳食摄入是人体暴露于PFCAs污染的最主要途径;PFCAs及其前体物质具有广泛的生物学毒性,如肝脏毒性、生殖毒性、发育毒性和遗传毒性等,且部分前体物质的毒性大于其本身毒性;PFCAs前体物质的生物转化研究主要聚焦于氟调聚醇类物质(fluorotelomer alcohol,FTOHs),已清晰的虹鳟体内生物转化研究结论为8:2 FTOH的主要代谢产物为全氧辛酸(PFOA),并伴有其他PFCAs的形成。已有的研究结果为生物体内尤其是水生生物体内PFCAs的源解析、污染特征及生物转化机制的相关研究提供了参考和依据。

基金项目:
国家重点研发计划(2017YFC1600705)
作者简介:
郭萌萌(1981-),女,硕士,高级工程师,研究方向为水产品质量安全检测与评价技术,guomm@ysfri.ac.cn
参考文献:
[1]Houde M, De Silva A O, Muir D C, et al. Monitoring of perfluorinated compounds in aquatic biota: an updated review [J]. Environ Sci Technol, 2011, 45(19):7962-7973.
[2]Feng M, He Q, Meng L, et al. Evaluation of single and joint toxicity of perfluorooctane sulfonate, perfluorooctanoic acid, and copper to Carassius auratus using oxidative stress biomarkers [J]. Aquat Toxicol, 2015, 161:108-116.
[3]杨琳, 李敬光. 全氟化合物前体物质生物转化与毒性研究进展 [J]. 环境化学, 2015, 34(4):649-655.
[4]Rand A A, Rooney J P, Butt C M, et al. Cellular toxicity associated with exposure to perfluorinated carboxylates (PFCAs) and their metabolic precursors [J]. Chem Res Toxicol, 2014, 27(1):42-50.
[5]Ellis D A. Degradation of fluorotelomer alcohols: a likely atmospheric source of perfluorinated carboxylic acids [J]. Environ Sci Technol, 2004, 38(12):3316-3321.
[6]Young C J, Mabury S A. Atmospheric perfluorinated acid precursors: chemistry, occurrence, and impacts [J]. Rev Environ Contam Toxicol, 2010, 208:1-109.
[7]Ahrens L, Plassmann M, Xie Z, et al. Determination of polyfluoroalkyl compounds in water and suspended particulate matter in the river Elbe and North Sea, Germany [J]. Front Environ Sci Engin China, 2009, 3(2):152-170.
[8]Zareitalabad P, Siemens J, Hamer M, et al. Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in surface waters, sediments, soils and wastewater-A review on concentrations and distribution coefficients [J]. Chemosphere, 2013, 91(6):725-732.
[9]Ellis D A, Mabury S A. Chemical ionization pathways of polyfluorinated chemicals--a connection to environmental atmospheric processes [J]. J Am Soc Mass Spectr, 2003, 14(10):1177-1191.
[10]Lee H,D′ Eon J,Mabury S A. Biodegradation of polyfluoroalkyl phosphates as a source of perfluorinated acids to the environment[J]. Environ Sci Technol, 2010, 44(9):3305-3310.
[11]Fraser A J, Webster T F, Watkins D J, et al. Polyfluorinated compounds in serum linked to indoor air in office environments [J]. Environ Sci Technol, 2012, 46(2):1209-1215.
[12]Shoeib M, Harner T, Lee S C, et al. Sorbent-impregnated polyurethane foam disk for passive air sampling of volatile fluorinated chemicals [J]. Anal Chem, 2008, 80(3):675-682.
[13]Prevedouros K, Cousins I T, Buck R C, et al. Sources, fate and transport of perfluorocarboxylates [J]. Environ Sci Technol, 2006, 40(1):32-44.
[14]EPA. U.S. 2010/15 PFOA Stewardship Program, EPA. U.S. Office of Pollution Prevention and Toxics[EB/OL].[2017-07-10]. http://www.epa.gov/ opptintr/pfoa/pubs/pfoastewardship.htm.
[15]IARC. Agents Classfied by the IARC Monographs, Volumes 1-111 [EB/OL].[2017-07-10]. http://monographs.iarc.fr/ENG/Classification/.
[16]徐睿,谭红,杨鸿波,等. 贵阳市市售食用油中全氟化合物污染水平研究 [J]. 食品科技,2014, 39(11):182-186.
[17]EPA. U.S. Fact Sheet: 2010/2015 PFOA Stewardship Program [EB/OL].[2017-07-10]. https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/fact-sheet-2010 2015-pfoa-stewardship-program.
[18]Domingo J L. Health risks of dietary exposure to perfluorinated compounds [J]. Environ Int, 2012, 40:187-195.
[19]李敬光. 全氟有机化合物:具有潜在健康风险的新型环境污染物 [J]. 中华预防医学杂志,2015,49(6):467-469.
[20]Remediation and Reuse Focus Group Federal Facilities Research Center. Perfluorinated Chemicals (PFCs): Perfluorooctanoic Acid (PFOA) & Perfluorooctane Sulfonate (PFOS) [M]. Washington:EPA, 2015.
[21]彭辉. 全氟辛酸和全氟辛磺酸饮用水基准制定及来源解析 [D]. 北京: 北京大学, 2013.
[22]Dinglasan M J, Ye Y, Edwards E A, et al. Fluorotelomer alcohol biodegradation yields poly- and perfluorinated acids [J]. Environ Sci Technol, 2004, 38(10): 2857-2864.
[23]Kim M H, Wang N, Chu K H. 6:2 Fluorotelomer alcohol (6:2 FTOH) biodegradation by multiple microbial species under different physiological conditions [J]. Appl Microbiol Biotechnol, 2014, 98(4): 1831-1840.
[24]Liu J X, Wang N, Szostek B, et al. 6-2 Fluorotelomer alcohol aerobic biodegradation in soil and mixed bacterial culture [J]. Chemosphere, 2010, 78(4):437-444.
[25]Liu J, Wang N, Buck R C, et al. Aerobic biodegradation of [14C]6:2 fluorotelomer alcohol in a flow-through soil incubation system [J]. Chemosphere, 2010, 80(7):716-723.
[26]D’Eon J C, Mabury S A. Exploring indirect sources of human exposure to perfluoroalkyl carboxylates (PFCAs): evaluating uptake, elimination, and biotransformation of polyfluoroalkyl phosphate esters (PAPs) in the rat [J]. Environ Health Persp, 2011, 119(3):344-350.
[27]Fasano W J, Carpenter S C, Gannon S A, et al. Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the rat [J]. Toxicol Sci, 2006, 91(2):341-355.
[28]Butt C M, Muir D C G, Mabury S A. Biotransformation of the 8:2 fluorotelomer acrylate in rainbow trout. 2. In vitro incubations with liver and stomach S9 fractions [J]. Environ Toxicol Chem, 2010, 29(12): 2736-2741.
[29]Butt C M, Muir D C G, Mabury S A. Elucidating the pathways of poly- and perfluorinated acid formation in rainbow trout [J]. Environ Sci Technol, 2010, 44(13): 4973-4980.
[30]陈红瑞, 张昱, 杨敏. 全氟化合物前体物氟调醇的检测方法、环境分布及转化研究进展[J]. 环境化学, 2015, 34(12): 2170-2178.
[31]Brace N O, Mackenzie A K. Polyfluoroalkyl phosphates:US15812861A[P]. 1963-03-26.
[32]Hagen D F, Belisle J, Johnson J D, et al. Characterization of fluorinated metabolites by a gas chromatographic-helium microwave plasma detector-The biotransformation of 1H,1H,2H,2H-perfluorodecanol to perfluorooctanoate [J]. Anal Biochem, 1981, 118(2):336-343.
[33]Himmelstein M W, Serex T L, Buck R C, et al. 8:2 fluorotelomer alcohol: A one-day nose-only inhalation toxicokinetic study in the Sprague-Dawley rat with application to risk assessment [J]. Toxicology, 2012, 291(1/2/3):122-132.
[34]Yang L, Wang Z, Shi Y, et al. Human placental transfer of perfluoroalkyl acid precursors: levels and profiles in paired maternal and cord serum [J]. Chemosphere, 2016, 144:1631-1638.
[35]Dinglasan-Panlilio M J, Mabury S A. Significant residual fluorinated alcohols present in various fluorinated materials [J]. Environ Sci Technol, 2006, 40(5):1447-53.
[36]Barber J L, Berger U, Chaemfa C, et al. Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe [J]. J Environ Monitor, 2007, 9(6):530-541.
[37]Li J, Del Vento S, Schuster J, et al. Perfluorinated compounds in the Asian atmosphere [J]. Environ Sci Technol, 2011, 45(17):7241-7248.
[38]Shoeib M, Harner T, M Webster G, et al. Indoor sources of poly- and perfluorinated compounds (PFCS) in Vancouver, Canada: implications for human exposure [J]. Environ Sci Technol, 2011, 45(19):7999-8005.
[39]赵洋洋, 姚义鸣, 常帅, 等. 室内空气和灰尘中全(多)氟烷基化合物的研究进展 [J]. 环境化学, 2015(4): 656-663.
[40]Lee H, D'eon J, Mabury S A, et al. Fate of polyfluoroalkyl phosphate diesters and their metabolites in biosolids-applied soil: biodegradation and plant uptake in greenhouse and field experiments [J]. Environ Sci Technol, 2013, 48(1):340-349.
[41]Fang S, Zhao S, Zhang Y, et al. Distribution of perfluoroalkyl substances (PFASs) with isomer analysis among the tissues of aquatic organisms in Taihu Lake, China [J]. Environ Pollut, 2014, 193:224-232.
[42]So M K, Taniyasu S, Yamashita N, et al. Perfluorinated compounds in coastal waters of Hong Kong, South China, and Korea [J]. Environ Sci Technol, 2004, 38(15):4056-4063.
[43]Yeung L W, Yamashita N, Taniyasu S, et al. A survey of perfluorinated compounds in surface water and biota including dolphins from the Ganges River and in other waterbodies in India [J]. Chemosphere, 2009, 76(1):55-62.
[44]Yamashita N, Kannan K, Taniyasu S, et al. A global survey of perfluorinated acids in oceans [J]. Mar Pollut Bull, 2005, 51(8):658-668.
[45]Ahrens L, Gerwinski W, Theobald N, et al. Sources of polyfluoroalkyl compounds in the North Sea, Baltic Sea and Norwegian Sea: Evidence from their spatial distribution in surface water [J]. Mar Pollut Bull, 2010, 60(2):255-260.
[46]杨永亮, 路国慧, 杨伟贤, 等. 沈阳地区水环境和生物样品中全氟化合物的污染分布特征 [J]. 环境科学学报, 2010, 30(10): 2097-2107.
[47]Ding H, Peng H, Yang M, et al. Simultaneous determination of mono- and disubstituted polyfluoroalkyl phosphates in drinking water by liquid chromatography-electrospray tandem mass spectrometry [J]. J Chromatogr A, 2012, 1227(5):245-252.
[48]Sinclair E, Kannan K. Mass loading and fate of perfluoroalkyl surfactants in wastewater treatment plants [J]. Environ Sci Technol, 2006, 40(5):1408-1414.
[49]Guo R, Sim W J, Lee E S, et al. Evaluation of the fate of perfluoroalkyl compounds in wastewater treatment plants [J]. Water Res, 2010, 44(11):3476-3486.
[50]Kim S K, Im J K, Kang Y M, et al. Wastewater treatment plants (WWTPs)-derived national discharge loads of perfluorinated compounds (PFCs) [J]. J Hazard Mater, 2012,201/202:82-91.
[51]Zhang T, Sun H, Gerecke AC, et al. Comparison of two extraction methods for the analysis of per- and polyfluorinated chemicals in digested sewage sludge [J]. J Chromatogr A, 2010, 1217(31):5026-5034.
[52]D’Eon J C, Crozier P W, Furdui V I, et al. Observation of commercial fluorinated material polyfluoroalkyl phosphoric acid diesters in human sera, wastewater treatment plant sludge, and paper fibers [J]. Environ Sci Technol, 2009, 43(12):4589-4594.
[53]Ahrens L, Xie Z, Ebinghaus R. Distribution of perfluoroalkyl compounds in seawater from Northern Europe, Atlantic Ocean, and Southern Ocean [J]. Chemosphere, 2010, 78(8):1011-1016.
[54]Loganathan B G, Lam P K S. Global contamination trends of persistent organic chemicals[M].Boca Raton,FA, USA:Crc Press, 2012.
[55]Sun H, Li F, Zhang T, et al. Perfluorinated compounds in surface waters and WWTPs in Shenyang, China: mass flows and source analysis [J]. Water Res, 2011, 45(15):4483-4490.
[56]Labadie P, Chevreuil M. Partitioning behaviour of perfluorinated alkyl contaminants between water, sediment and fish in the Orge River (nearby Paris, France) [J]. Environ Pollut, 2011, 159(2):391-397.
[57]Tomy G T, Budakowski W, Halldorson T, et al. Fluorinated organic compounds in an eastern Arctic marine food web [J]. Environ Sci Technol, 2004, 38(24):6475-6481.
[58]Nania V, Pellegrini G E, Fabrizi L, et al. Monitoring of perfluorinated compounds in edible fish from the Mediterranean Sea [J]. Food Chem, 2009, 115(3):951-957.
[59]Veronika S, Darina L, Jan P, et al. Perfluoroalkyl substances (PFASs) and other halogenated compouds in fish from the upper Labe River basin [J]. Chemosphere, 2015, 129:170-178.
[60]Pan Y, Shi Y, Wang Y, et al. Investigation of perfluorinated compounds (PFCs) in mollusks from coastal waters in the Bohai Sea of China [J]. J Environ Monitor, 2010, 12(2):508-513.
[61]夏慧, 敖俊杰, 袁涛. 室内灰尘中全氟化合物的污染状况与人体暴露水平评估 [J]. 生态毒理学报, 2016(02): 223-230.
[62]Fraser A J, Webster T F,Watkins D J,et al. Polyfluorinated compounds in dust from homes, offices, and vehicles as predictors of concentrations in office workers′ serum [J]. Environ Int, 2013, 60(4):128-136.
[63]Olsen G W, Ellefson M E, Mair D C, et al. Analysis of a homologous series of perfluorocarboxylates from American Red Cross adult blood donors, 2000-2001 and 2006 [J]. Environ Sci Technol, 2011,45(19):8022-8029.
[64]金一和, 舒为群, 丁梅, 等. 两地区一般人群血清中PFOS和PFOA污染特征比较 [J]. 毒理学杂志, 2005, 19(3):318-319.
[65]Nilsson H, Krrman A, Rotander A, et al. Inhalation exposure to fluorotelomer alcohols yield perfluorocarboxylates in human blood? [J]. Environ Sci Technol, 2010, 44(19): 7717-7722.
[66]Tao L, Kannan K, Wong C M, et al. Perfluorinated chompounds in human milk from Massachusetts, USA [J]. Environ Sci Technol, 2008, 42(8):3096-3101.
[67]Weihe P, Kato K, Calafat A M, et al. Serum concentrations of polyfluoroalkyl compounds in faroese whale meat consumers [J]. Environ Sci Technol, 2008, 42(16):6291-6295.
[68]Boudreau T M, Sibley P K, Mabury S A, et al. Laboratory evaluation of the toxicity of perfluorooctane sulfonate (PFOS) on Selenastrum capricornutum, Chlorella vulgaris, Lemna gibba, Daphnia magna, and Daphnia pulicaria [J]. Arch Environ Con Tox, 2003, 44(3):307-313.
[69]Lau C, Thibodeaux J R, Hanson R G, et al. Effects of perfluorooctanoic acid exposure during pregnancy in the mouse [J]. Toxicol Sci, 2006, 90(2):510-518.
[70]Mulkiewicz E, Jastorff B, Skadanowski A C, et al. Evaluation of the acute toxicity of perfluorinated carboxylic acids using eukaryotic cell lines, bacteria and enzymatic assays [J]. Environ Toxicol Phar, 2007, 23(3):279-285.
[71]Lau C, Anitole K, Hodes C, et al. Perfluoroalkyl acids: a review of monitoring and toxicological findings [J]. Toxicol Sci, 2007, 99(2):366-394.
[72]Luebker D J, Hansen K J, Bass N M, et al. Interactions of fluorochemicals with rat liver fatty acid-binding protein [J]. Toxicology, 2002, 176(3):175-185.
[73]Cheng X, Klaassen C D. Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors [J]. Toxicol Sci, 2008, 106(1):29-36.
[74]Liu C, Yu K, Shi X, et al. Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus) [J]. Aquat Toxicol, 2007, 82(2):135-143.
[75]Kudo N, Iwase Y, Okayachi H, et al. Induction of hepatic peroxisome proliferation by 8-2 telomer alcohol feeding in mice: formation of perfluorooctanoic acid in the liver [J]. Toxicol Sci, 2005, 86(2):231-238.
[76]DePierre J W. Effects on rodents of perfluorofatty acids [M]. Berlin: Springer Berlin Heidelberg, 2002. 
[77]Mylchreest E, Munley S M, Kennedy G L Jr. Evaluation of the developmental toxicity of 8-2 telomer B alcohol [J]. Drug Chem Toxicol, 2005, 28(3):315-328.
[78]Case M T, York R G, Christian M S. Rat and rabbit oral developmental toxicology studies with two perfluorinated compounds [J]. Int J Toxicol, 2001, 20(2):101-109.
[79]Lee Y J, Kim M K, Bae J, et al. Concentrations of perfluoroalkyl compounds in maternal and umbilical cord sera and birth outcomes in Korea [J]. Chemosphere, 2013, 90(5):1603-1609. 
[80]Wu K, Xu X, Peng L, et al. Association between maternal exposure to perfluorooctanoic acid (PFOA) from electronic waste recycling and neonatal health outcomes [J]. Environ Int, 2012, 48(2):1-8.
[81]Guruge K S, Yeung L W, Yamanaka N, et al. Gene expression profiles in rat liver treated with perfluorooctanoic acid (PFOA) [J]. Toxicol Sci, 2006, 89(1):93-107.
[82]Wang T, Lin Z, Yin D, et al. Hydrophobicity-dependent QSARs to predict the toxicity of perfluorinated carboxylic acids and their mixtures [J]. Environ Toxicol Phar, 2011, 32(2):259-265.
[83]Butenhoff J L, Bjork J A, Chang S C, et al. Toxicological evaluation of ammonium perfluorobutyrate in rats: Twenty-eight-day and ninety-day oral gavage studies [J]. Reprod Toxicol, 2011, 33(4):513-530.
[84]Phillips M M, Dinglasan-Panlilio M J, Mabury S A, et al. Chronic toxicity of fluorotelomer acids to Daphnia magna and Chironomus dilutes [J]. Environ Toxicol Chem, 2010, 29(5):1123-1131.
[85]Nabb D L, Szostek B, Himmelstein M W, et al. In vitro metabolism of 8-2 fluorotelomer alcohol: interspecies comparisons and metabolic pathway refinement [J]. Toxicol Sci, 2007, 100(2):333-344.
[86]Fasano W J, Sweeney L M, Mawn M P, et al. Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats [J]. Chem Biol Interact, 2009, 180(2):281-295.
[87]Kim M H, Wang N, McDonald T, et al. Biodefluorination and biotransformation of fluorotelomer alcohols by two alka-degrading Pseudomonas strains [J]. Biotechnol Bio-eng, 2012, 109(12): 3041-3048.
[88]Wang N, Szostek B, Buck R C, et al. 8-2 fluorotelomer alcohol aerobic soil biodegradation: pathways, metabolites, and metabolite yields [J]. Chemosphere, 2009, 75:1089-1096.
[89]Zhang S, Szostek B, Mccausland P K, et al. 6:2 and 8:2 fluorotelomer alcohol anaerobic biotransformation in digester sludge from a WWTP under methanogenic conditions [J]. Environ Sci Technol, 2013, 47(9):4227-4235.
[90]Martin J W, Mabury S A, O’Brien P J. Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes [J]. Chem Bio Interact, 2005, 155(3):165-180.
[91]Zhao L, Folsom P W, Wolstenholme B W, et al. 6:2 Fluorotelomer alcohol biotransformation in an aerobic river sediment system [J]. Chemosphere, 2013, 90(2):203-209.
[92]Tseng N, Wang N, Szostek B, et al. Biotransformation of 6:2 Fluorotelomer Alcohol (6:2 FTOH) by a wood-rotting fungus [J]. Environ Sci Technol, 2014, 48(7):4012-4020.
[93]Russell M H, Himmelstein M W, Buck R C. Inhalation and oral toxicokinetics of 6:2 FTOH and its metabolites in mammals [J]. Chemosphere, 2015, 120:328-335.
[94]Gannon S A,Nabb D L,Snow T A,et al.P34—In vitro metabolism of 6-2 fluorotelomer alcohol in rat,mouse,and human hepatocytes [J]. Reprod Toxicol, 2012, 33(4):610-611.
[95]Serex T,Anand S,Munley S,et al.Toxicological evaluation of 6:2 fluorotelomer alcohol [J].Toxicology, 2014, 319: 1-9.
[96]赵立杰, 王宁, 周萌, 等. 6-2氟调醇在沉积物中的有氧降解途径研究 [C]//中国化学会第28届学术年会论文集. 成都:中国化学会, 2012.
[97]何娜, 周萌, 汪磊, 等. 6-2氟调醇在活性污泥中的降解 [J]. 环境科学学报, 2013,33(2): 383-388.
[98]赵淑艳, 马新新, 钟文钰, 等. 蚯蚓对土壤中8:2与10:2氟调醇的生物富集与转化[J]. 中国科学(化学), 2014(11):1823-1830.
[99]Butt C M , Muir D C G, Mabury S A. Biotransformation of the 8:2 fluorotelomer acrylate in rainbow trout. 1. In vivo dietary exposure [J]. Environ Toxicol Chem, 2010, 29(12): 2726-2735.
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